Tagrisso

Before taking osimertinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Tagrisso may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Tagrisso, tell your doctor or pharmacist your medical history. Osimertinib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using osimertinib,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using osimertinib safely. Tagrisso may cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages. Osimertinib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Tell your health care professional that you are using osimertinib before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Tagrisso, especially QT prolongation (see above). Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using osimertinib. Osimertinib may harm an unborn baby. Women of childbearing age should ask about reliable forms of birth control while using Tagrisso and for 6 weeks after the last dose. Men with female partners of childbearing age should use reliable forms of birth control while using Tagrisso and for 4 months after the last dose. If you or your partner becomes pregnant, or think you may be pregnant, talk to your doctor right away about the risks and benefits of Tagrisso. It is unknown if Tagrisso passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using Tagrisso and for 2 weeks after the end of treatment. Consult your doctor before breast-feeding.