Rifabutin
(Rifabutin)Rifabutin Overview
Rifabutin is used alone or with another medication to help prevent a certain serious infection (Mycobacterium avium complex-MAC). Rifabutin is known as a rifamycin antibiotic. It works by stopping the growth of bacteria. This antibiotic treats and prevents only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
How to Use Rifabutin
Take Rifabutin by mouth with or without food, usually once or twice daily or as directed by your doctor. Take Rifabutin with food if stomach upset occurs. For the treatment of tuberculosis, Rifabutin is sometimes taken twice weekly. Dosage of Rifabutin is based on your medical condition, weight, interacting drugs, and response to treatment. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take Rifabutin at the same time(s) every day. Continue to take Rifabutin until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early or skipping doses may allow the bacteria to continue to grow, which may result in a return of the infection and cause the infection to be more difficult to treat (resistant). Tell your doctor if your condition lasts or gets worse.
Rifabutin Precautions
Before taking rifabutin, tell your doctor or pharmacist if you are allergic to it; or to other rifamycins (such as rifampin); or if you have any other allergies. Rifabutin may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Rifabutin, tell your doctor or pharmacist your medical history,kidney disease, liver disease, a certain blood disorder (porphyria). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Rifabutin may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using rifabutin before having any immunizations/vaccinations. During pregnancy, Rifabutin should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if Rifabutin passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding. If you have HIV disease, do not breast-feed because breast milk can transmit HIV.
Rifabutin Misdose
If you miss a dose of Rifabutin, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Rifabutin Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.azole antifungals (such as fluconazole, itraconazole, voriconazole), ciprofloxacin, macrolide antibiotics (such as clarithromycin). Rifabutin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aprepitant/fosaprepitant, lurasidone, phenytoin, ranolazine, suvorexant, tacrolimus, tasimelteon, "blood thinners" (such as warfarin), calcium channel blockers (such as diltiazem, verapamil), certain combination products used to treat chronic hepatitis C (ombitasvir/paritaprevir/ritonavir), among others. Rifabutin may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using Rifabutin. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Rifabutin Side Effects
Diarrhea, stomach upset, changes in taste, or nausea/vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Rifabutin may cause urine, sweat, saliva, or tears to turn brown-orange. This effect is harmless and will disappear when the medication is stopped. However, dentures and contact lenses may be permanently stained. Remember that Rifabutin has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Rifabutin do not have serious side effects. Tell your doctor right away if you have any serious side effects,nausea/vomiting that doesn't stop, easy bleeding/bruising, muscle weakness/pain, joint pain/swelling, eye pain/redness, vision problems, chest pain/pressure, unusual weakness/tiredness, dark urine, yellowing eyes/skin. Rifabutin may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped.diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. A very serious allergic reaction to Rifabutin is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Rifabutin Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Rifabutin when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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