Astagraf XL
(Tacrolimus ER)-
All Strengths
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0.5mg
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1mg
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3mg
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5mg
Astagraf XL 0.5mg
Extended Release CapsulesMarketed as Advagraf Prolonged Release in United Kingdom
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Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
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Astagraf XL Drug Information
Are you paying too much for Astagraf XL? Save up to 80% when purchasing your prescription drugs from Universal Drugstore. Our prescription service aspires to conveniently provide you with affordable medications at the lowest prices in Canada and internationally.
We’re working with a number of Canadian and international pharmacy partners, all licensed by their qualified governmental regulatory bodies. By collaborating with our partners, we are able to offer a wide range of brand and generic medications at very competitive prices. You can obtain discount prescription drugs through our online pharmacy. Our prices are already up to 80% lower than your local pharmacy. We are committed to providing you with the best service and prices. This is why we’ll match the price of any of our online pharmacy competitors who require a valid prescription.
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How Long Does It Take to Receive My Astagraf XL Order?
You can easily place an order on our website in under 5 minutes. First you need to set up an account with us, create a payment method, and send us your prescriptions. Alternatively, you can order by downloading our order form or by placing an order over the phone. Delivery can take approximately 2 weeks to North America, and 4 weeks to other countries.
Astagraf XL Overview
Tacrolimus is used with other medications to prevent rejection of a kidney, heart, liver, or lung transplant. Astagraf XL belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.
Astagraf XL Warnings
Tacrolimus lowers the body's ability to fight an infection/disease (immunosuppression). This may increase your risk of developing an infection or certain types of cancer (such as skin cancer, lymphoma). To reduce the risk of these serious side effects, take Astagraf XL at the lowest effective dose as directed by your doctor. Keep all medical and laboratory appointments.unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen glands, night sweats, unexplained weight loss, signs of infection (such as sore throat that doesn't go away, fever).
How to Use Astagraf XL
Read the Patient Information Leaflet if available from your pharmacist before you start taking tacrolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Astagraf XL by mouth with or without food as directed by your doctor, usually every 12 hours. If you have nausea or an upset stomach, you may take Astagraf XL with food, although this may cause your body to absorb less of the drug. However, you must choose one way (with food or without food) and always take Astagraf XL the same way so that your body always absorbs the same amount of drug. Consult your doctor or pharmacist for more details. If you are taking the capsules, swallow them whole. Do not open or crush the capsules. If you are using the granules, read the manufacturer's Instructions for Use first. Use only non-plastic cups, spoons, or oral syringes when preparing or taking a dose. Do not sprinkle the granules on food. Open up the prescribed number of packets for your dose and mix the granules in a cup with 1 to 2 tablespoons (15 to 30 milliliters) of room temperature water and stir well. Drink the dose immediately. You may use an oral syringe to give the dose. Rinse the cup or syringe with the same amount of water and drink the rinse water to make sure the complete dose is taken. Do not prepare the granule mixture ahead of time. Do not save any of the mixture for later use. Dosage of Astagraf XL is based on your weight, medical condition, blood test results (such as tacrolimus trough levels), and response to therapy. Tacrolimus is available in different formulations (such as immediate and extended-release). Do not switch between different forms of tacrolimus without consulting your doctor. Do not increase your dose or take Astagraf XL more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased. Also, do not stop taking Astagraf XL without your doctor's approval. Take Astagraf XL regularly in order to get the most benefit from it. It is important to take all doses on time to keep the amount of medicine in your body at a constant level. Remember to take it at the same times each day. Avoid eating grapefruit or drinking grapefruit juice while being treated with Astagraf XL unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details. Since Astagraf XL can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle Astagraf XL or breathe the dust from the capsules. Inform your doctor if your condition worsens.
Astagraf XL Precautions
Before taking tacrolimus, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications (such as sirolimus); or if you have any other allergies. Astagraf XL may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Astagraf XL, tell your doctor or pharmacist your medical history,mineral imbalances (such as high potassium), kidney disease, any recent/current infections, cancer, liver disease, high blood pressure, diabetes. Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tacrolimus,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using tacrolimus safely. Astagraf XL may increase your risk of developing skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tacrolimus can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Tell your health care professional that you are using tacrolimus before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). Astagraf XL may increase your potassium levels. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Astagraf XL, especially QT prolongation (see above). Since Astagraf XL can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle Astagraf XL or breathe the dust from the capsules. Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using tacrolimus. Tacrolimus may harm an unborn baby. Men and women using Astagraf XL should ask about reliable forms of birth control before and while using Astagraf XL. If you or your partner become pregnant, talk to your doctor right away about the risks and benefits of Astagraf XL. Do not stop taking Astagraf XL unless directed by your doctor. Astagraf XL passes into breast milk and the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before breast-feeding.
Astagraf XL Misdose
If you miss a dose of Astagraf XL, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Astagraf XL Interactions
See also How to Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aluminum/magnesium antacid, cyclosporine, sirolimus, temsirolimus, ziprasidone, other drugs that may increase the level of potassium in the blood (such as "water pills" including amiloride, spironolactone), other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab). Other medications can affect the removal of tacrolimus from your body, which may affect how tacrolimus works. Examples include cimetidine, danazol, nefazodone, ethinyl estradiol, methylprednisolone, St. John's wort, azole antifungals (such as itraconazole, voriconazole), HIV protease inhibitors (such as nelfinavir), rifamycins (such as rifampin, rifabutin), ritonavir, certain anti-seizure drugs (such as phenobarbital, phenytoin), among others.
Astagraf XL Side Effects
Shaking, headache, diarrhea, nausea/vomiting, upset stomach, loss of appetite, trouble sleeping, and numbness/tingling of the hands/feet may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that Astagraf XL has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Astagraf XL do not have serious side effects. Tell your doctor right away if you have any serious side effects,nausea/vomiting that doesn't stop, mental/mood changes, dizziness, signs of kidney problems (such as change in the amount of urine), pounding heartbeat, symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), hearing problems (such as hearing loss, ringing in the ears), pain/redness/swelling of arms or legs, easy bruising/bleeding, muscle pain/cramp/weakness, yellowing skin/eyes, dark urine, severe stomach/abdominal pain, severe leg pain. Astagraf XL may also increase your risk of getting a rare but very serious (sometimes fatal) brain infection (progressive multifocal leukoencephalopathy-PML).clumsiness, loss of coordination, weakness, sudden change in your thinking (such as confusion, difficulty concentrating), difficulty moving your muscles, problems with speech, seizure, vision changes. Get medical help right away if you have any very serious side effects,fainting, fast/irregular heartbeat, severe dizziness, chest/jaw/left arm pain, black stools, vomit that looks like coffee grounds. Astagraf XL may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication. Tacrolimus may cause diabetes.increased thirst/hunger, frequent urination. A very serious allergic reaction to Astagraf XL is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Astagraf XL Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Astagraf XL when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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