Amiloride/HCTZ
(Amiloride/HCTZ)Amiloride/HCTZ Overview
Amiloride/HCTZ is used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.amiloride and hydrochlorothiazide. Both medications are "water pills" (diuretics) and cause your body to get rid of extra salt and water. This effect may increase the amount of urine you make when you first start the product. Amiloride also helps to treat or prevent low blood potassium levels.
Amiloride/HCTZ Warnings
Amiloride/HCTZ can rarely cause high potassium levels (hyperkalemia). This effect is more likely to occur in older adults and in patients with kidney disease, diabetes, or a serious illness. Potassium levels must be closely monitored on a regular basis while taking Amiloride/HCTZ. If not treated, very high potassium levels can sometimes be fatal. Tell your doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular heartbeat, numb/tingling skin.
How to Use Amiloride/HCTZ
Take Amiloride/HCTZ by mouth with food as directed by your doctor, usually once or twice daily. If you take Amiloride/HCTZ too close to bedtime, you may need to wake up to urinate. It is best to take Amiloride/HCTZ at least 4 hours before your bedtime. If you have any questions about how and when to take Amiloride/HCTZ, ask your doctor or pharmacist. The Dosage of Amiloride/HCTZ is based on your medical condition and response to treatment. Use Amiloride/HCTZ regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking Amiloride/HCTZ even if you feel well. Most people with high blood pressure do not feel sick. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take Amiloride/HCTZ at least 4 hours before or at least 4 to 6 hours after these medications. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).
Amiloride/HCTZ Precautions
Before taking Amiloride/HCTZ, tell your doctor or pharmacist if you are allergic to amiloride or hydrochlorothiazide; or if you have any other allergies. Amiloride/HCTZ may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Amiloride/HCTZ, tell your doctor or pharmacist your medical history,electrolyte imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, dehydration, lupus, gout, high levels of fats in the blood (cholesterol/triglycerides), skin cancer. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Amiloride/HCTZ may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Dehydration from too much sweating, vomiting, or diarrhea can also lower your blood pressure and worsen dizziness. Drink plenty of fluids to prevent these effects and dehydration. If you are on restricted fluid intake, consult your doctor for further instructions. Contact your doctor if you are unable to drink fluids or if you have diarrhea/vomiting that doesn't stop. Amiloride/HCTZ may make you more sensitive to the sun. It may also increase your risk for skin cancer, especially if you take it for a long time. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned, have skin blisters/redness, or notice new or changed moles/skin lesions. If you have diabetes, Amiloride/HCTZ may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Amiloride/HCTZ may affect the potassium levels in your blood. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. During pregnancy, Amiloride/HCTZ should be used only when clearly needed. Discuss the risks and benefits with your doctor. Hydrochlorothiazide passes into breast milk. It is unknown if amiloride passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.
Amiloride/HCTZ Misdose
If you miss a dose of Amiloride/HCTZ, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Amiloride/HCTZ Interactions
See also How To Use and Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.dofetilide, lithium, sodium phosphate products, other products that may affect potassium levels (such as eplerenone, tacrolimus, cyclosporine, birth control pills containing drospirenone, other diuretics like spironolactone/triamterene, ACE inhibitors like benazepril/captopril, angiotensin receptor antagonists like losartan/valsartan). Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Amiloride/HCTZ may interfere with certain laboratory tests (including glucose tolerance testing, parathyroid test, protein-bound iodide test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Amiloride/HCTZ.
Amiloride/HCTZ Side Effects
Headache, dizziness, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that Amiloride/HCTZ has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Amiloride/HCTZ do not have serious side effects. Amiloride/HCTZ may cause dehydration and electrolyte imbalance.very dry mouth, extreme thirst, muscle cramps, weakness, fast heartbeat, severe dizziness, confusion, fainting, seizures. Tell your doctor right away if you have any serious side effects,nausea/vomiting that doesn't stop, yellowing eyes/skin, dark urine, joint pain, signs of kidney problems (such as change in the amount of urine), decrease in vision, eye pain. A very serious allergic reaction to Amiloride/HCTZ is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Amiloride/HCTZ Storage
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Amiloride/HCTZ when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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